Advanced Morphologic Analysis for Diagnosing Allograft Rejection
نویسندگان
چکیده
منابع مشابه
Sinusoidal endotheliitis as a histological parameter for diagnosing acute liver allograft rejection
AIM To investigated the feasibility of using sinusoidal endotheliitis (SE) as a histological marker for liver allograft rejection. METHODS We compared the histological features of 88 liver allograft biopsies with acute cellular rejection (ACR) and 59 cases with no evidence of ACR. SE was scored as: (1) focal linear lifting up of the endothelial cells by lymphocytes with no obvious damage to a...
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The cornea is avascular, enjoys relative immune privilege, and immunosuppressive treatment can be directly applied: yet data from all available reports indicate that allogeneic rejection is the commonest cause of corneal graft failure. In Australia, 5 year actuarial corneal graft survival is 72%: irreversible rejection accounts for at least 33% of all graft failures.' Graft survival is much sho...
متن کاملSuppression of Allograft Rejection
Suppressor T cells (Ts) 1 have been described in many allogeneic systems and may play a role in preventing allograft rejection in tolerized (1-5), antigenpretreated (6-9), passively enhanced (10, 11), or cyclosporin A-treated (12, 13) recipients with long-term surviving transplants. The interactions between the Ts and their target cells are largely undefined. If Ts cells were specific for the a...
متن کاملRejection of the kidney allograft.
Copyright © 2010 Massachusetts Medical Society. The science of kidney transplantation has progressed considerably in the past half-century largely because of an improved understanding of the role of the immune system in allograft rejection, the disentanglement of the molecular mechanisms underlying graft failure, and better management of immunosuppression.1,2 Rejection has always been the major...
متن کاملMechanisms of Renal Allograft Rejection
Rejection is the major cause of graft failure, and if the injury to the tubules and glomeruli is severe, the kidney may not recover. It is therefore important to diagnose acute rejection as soon as possible to institute prompt antirejection therapy. Generally, the success with which rejection can be reversed by immunosuppressive agents determines the chance of long-term success of the transplan...
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ژورنال
عنوان ژورنال: Transplantation
سال: 2018
ISSN: 0041-1337
DOI: 10.1097/tp.0000000000002189